Did you know that the older your epigenetic age relative to your chronological age the greater your risk of developing cancer and dying from cancer? The study below found exactly this.
Epigenetic age is based on an algorithm that uses DNA methylation measurements to describe biological age at the level of tissues, cells, and organs. Epigenetic age often does not parallel chronological age.
Measuring epigenetic age assesses genetic pathways related to both cancer development and aging in general (e.g., DNA damage, cellular proliferation, and oxidative stress), which makes this simple blood test a predictive biomarker for cancer risk, metastasis, and mortality in addition to serving as an indicator of aging.
DNA methylation, an epigenetic modification which alters how DNA is read and expressed without altering the underlying sequence, can show age-related changes. These modifications are so accurate that chronological age in humans can be predicted +/- 3.6 years from any tissue or fluid in the body (Horvath S. 2013). This is by far the best biomarker of age available and is referred to as the “epigenetic clock.” Dr. Steve Horvath’s epigenetic aging clock is considered to be the golden standard of aging clocks.
Analysis of DNA methylation can also provide information on biological age, which is a measure of how well your body functions compared to your chronological age. For instance, people suffering from fatty liver disease have a faster ticking clock, while centenarians have a slower clock.
Learn more about science of the epigenetic clock in the video, below.
myDNAge® Is My Favorite Blood Test To Measure Your Epigenetic Age
The myDNAge® test is an epigenetic age determination test. The myDNAge® test is based on Dr. Horvath’s epigenetic aging clock, and utilizes technology to analyze DNA methylation patterns of over 1,000 loci on the human genome to generate epigenetic age predictions.
The myDNAge® test evaluates chemical modifications on DNA known as methylation marks. Numerous studies show that lifestyle and environmental factors can alter genetic DNA methylation patterns in our cells – for example, stress, exercise, smoking, and diet. In short, research shows that our lifestyle and the daily choices we make can influence the methylation marks on our DNA.
See a sample report, below. The tested subject is 36 years old, but based on her epigenetic methylation patterns her DNAge is only 34 years old. In comparison to other 36 year olds, she is biologically younger than 69% of them. This means that her risk of developing or dying from cancer and other chronic diseases is lower than most in her age group. Furthermore, her epigenetic clock suggests that she should live 2 years longer than her age peers.